TRPM4 Antikörper (N-Term)
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- Target Alle TRPM4 Antikörper anzeigen
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TRPM4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- ELLTVYSSED GSEEFETIVL KALVKACGSS EASAYLDELR LAVAWNRVDI
- Homologie
- Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against TRPM4. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM4
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1214 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells." in: PLoS ONE, Vol. 7, Issue 8, pp. e43859, (2012) (PubMed).
: "
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KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells." in: PLoS ONE, Vol. 7, Issue 8, pp. e43859, (2012) (PubMed).
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- Target
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
- Andere Bezeichnung
- TRPM4 (TRPM4 Produkte)
- Synonyme
- PFHB1B antikoerper, TRPM4B antikoerper, LTrpC-4 antikoerper, Mls2s antikoerper, 1110030C19Rik antikoerper, AW047689 antikoerper, LTRPC4 antikoerper, TRPM4 antikoerper, transient receptor potential cation channel subfamily M member 4 antikoerper, transient receptor potential cation channel, subfamily M, member 4 antikoerper, TRPM4 antikoerper, Trpm4 antikoerper
- Hintergrund
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TRPM4 is a calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. TRPM4 mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. TRPM4 is involved in myogenic constriction of cerebral arteries. It controls insulin secretion in pancreatic beta-cells. TRPM4 may also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload.
Alias Symbols: FLJ20041, TRPM4B, PFHB1B
Protein Interaction Partner: FUS, UBC, TRPM4,
Protein Size: 1214 - Molekulargewicht
- 134 kDa
- Gen-ID
- 54795
- NCBI Accession
- NM_017636, NP_060106
- UniProt
- Q8TD43
- Pathways
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
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