PITX2 Antikörper (N-Term)

Produktnummer ABIN2776373

Produktdetails anti-PITX2 Antikörper

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Schwein, Kaninchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PITX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: SAVSSSSCHH PQPLAMASVL APGQPRSLDS SKHRLEVHTI SDTSSPEAAE

Homologie: Cow: 100%, Dog: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 324 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PITX2 Antikörper (ABIN2776373)

Hatou, Yoshida, Higa, Miyashita, Inagaki, Okano, Tsubota, Shimmura: "Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/?-catenin signaling." in: Stem cells and development, Vol. 22, Issue 5, pp. 828-39, (2013) (PubMed).

Details zu PITX2

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Andere Bezeichnung: PITX2 (PITX2 Produkte)

Synonyme: ARP1 antikoerper, Brx1 antikoerper, IDG2 antikoerper, IGDS antikoerper, IGDS2 antikoerper, IHG2 antikoerper, IRID2 antikoerper, Otlx2 antikoerper, PTX2 antikoerper, RGS antikoerper, RIEG antikoerper, RIEG1 antikoerper, RS antikoerper, 9430085M16Rik antikoerper, Brx1a antikoerper, Brx1b antikoerper, Munc30 antikoerper, Pitx2a antikoerper, Pitx2b antikoerper, Pitx2c antikoerper, Pitx2cbeta antikoerper, Ptx2 antikoerper, Rieg antikoerper, pitx2a antikoerper, pitx2c antikoerper, zgc:110508 antikoerper, XPtx2b antikoerper, xPtx2 antikoerper, xpitx2 antikoerper, arp1 antikoerper, brx1 antikoerper, idg2 antikoerper, igds antikoerper, igds2 antikoerper, ihg2 antikoerper, irid2 antikoerper, otlx2 antikoerper, pitx2-A antikoerper, ptx2 antikoerper, rgs antikoerper, rieg antikoerper, rieg1 antikoerper, pitx-2 antikoerper, pitx2 antikoerper, paired like homeodomain 2 antikoerper, paired-like homeodomain transcription factor 2 antikoerper, paired-like homeodomain 2 antikoerper, paired like homeodomain 2 S homeolog antikoerper, paired like homeodomain 2 L homeolog antikoerper, PITX2 antikoerper, Pitx2 antikoerper, pitx2 antikoerper, pitx2.S antikoerper, pitx2.L antikoerper

Hintergrund: The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
Alias Symbols: RS, RGS, ARP1, Brx1, IDG2, IGDS, IHG2, PTX2, RIEG, IGDS2, IRID2, Otlx2, RIEG1
Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
Protein Size: 324

Molekulargewicht: 36 kDa

Gen-ID: 5308

NCBI Accession: NM_000325, NP_000316

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development