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HSBP1 Antikörper (N-Term)

HSBP1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2776380
  • Target Alle HSBP1 Antikörper anzeigen
    HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))
    Bindungsspezifität
    • 8
    • 5
    • 1
    N-Term
    Reaktivität
    • 27
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen
    Wirt
    • 24
    • 2
    • 1
    Kaninchen
    Klonalität
    • 25
    • 2
    Polyklonal
    Konjugat
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HSBP1 Antikörper ist unkonjugiert
    Applikation
    • 11
    • 11
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Sequenz
    AETDPKTVQD LTSVVQTLLQ QMQDKFQTMS DQIIGRIDDM SSRIDDLEKN
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%
    Produktmerkmale
    This is a rabbit polyclonal antibody against HSBP1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human HSBP1
    Top Product
    Discover our top product HSBP1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 76 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tai, McFall, Huang, Demeler, Fox, Brubaker, Radhakrishnan, Morimoto: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, (2002) (PubMed).

  • Target
    HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))
    Andere Bezeichnung
    HSBP1 (HSBP1 Produkte)
    Synonyme
    HSBP1 antikoerper, npc-a-13 antikoerper, NPC-A-13 antikoerper, hsbp1 antikoerper, hsbp1a antikoerper, 0610007A03Rik antikoerper, AA408769 antikoerper, Hsp25 antikoerper, zgc:73224 antikoerper, heat shock factor binding protein 1 like 1 antikoerper, heat shock factor binding protein 1 antikoerper, Heat shock factor binding protein 1 antikoerper, heat shock factor binding protein 1 S homeolog antikoerper, heat shock factor binding protein 1 L homeolog antikoerper, heat shock factor binding protein 1b antikoerper, HSBP1L1 antikoerper, HSBP1 antikoerper, Bm1_07370 antikoerper, hsbp1.S antikoerper, hsbp1 antikoerper, hsbp1.L antikoerper, Hsbp1 antikoerper, hsbp1b antikoerper
    Hintergrund
    The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
    Alias Symbols: DKFZp686D1664, DKFZp686O24200, NPC-A-13
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-7, LNX1, KIAA1217, CCHCR1, CCDC53, SDCBP, KIFC3, HSBP1, UBC, VCP, RRBP1, RB1CC1, HSF1, HSPA1A, HSPA4,
    Protein Size: 76
    Molekulargewicht
    8 kDa
    Gen-ID
    3281
    NCBI Accession
    NM_001537, NP_001528
    UniProt
    O75506
    Pathways
    SARS-CoV-2 Protein Interaktom
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