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ZIC2 Antikörper (C-Term)

ZIC2 Reaktivität: Human, Ratte, Maus, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2776475
  • Target Alle ZIC2 Antikörper anzeigen
    ZIC2
    Bindungsspezifität
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 18
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Meerschweinchen
    Wirt
    • 31
    • 2
    • 1
    Kaninchen
    Klonalität
    • 32
    • 2
    Polyklonal
    Konjugat
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ZIC2 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 13
    • 13
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS
    Homologie
    Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%
    Produktmerkmale
    This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 532 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

    Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

    Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

    McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

  • Target
    ZIC2
    Andere Bezeichnung
    ZIC2 (ZIC2 Produkte)
    Synonyme
    HPE5 antikoerper, Ku antikoerper, cb851 antikoerper, fb26a03 antikoerper, wu:fb26a03 antikoerper, zic2 antikoerper, zic2.1 antikoerper, hpe5 antikoerper, hm:zeh0655 antikoerper, id:ibd5017 antikoerper, zic2.2 antikoerper, zic2l antikoerper, Zic family member 2 antikoerper, zinc finger protein of the cerebellum 2 antikoerper, zic family member 2 (odd-paired homolog, Drosophila), a antikoerper, Zic family member 2 L homeolog antikoerper, zic family member 2 (odd-paired homolog, Drosophila) b antikoerper, ZIC2 antikoerper, Zic2 antikoerper, zic2a antikoerper, zic2.L antikoerper, zic2b antikoerper
    Hintergrund
    ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
    Alias Symbols: HPE5
    Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
    Protein Size: 532
    Molekulargewicht
    55 kDa
    Gen-ID
    7546
    NCBI Accession
    NM_007129, NP_009060
    UniProt
    O95409
    Pathways
    Tube Formation
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