DGCR8 Antikörper (N-Term)
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- Target Alle DGCR8 Antikörper anzeigen
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DGCR8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- DKKDEENELD QEKRVEYAVL DELEDFTDNL ELDEEGAGGF TAKAIVQRDR
- Homologie
- Cow: 85%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 77%
- Produktmerkmale
- This is a rabbit polyclonal antibody against DGCR8. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR8
- Top Product
- Discover our top product DGCR8 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 773 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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DGCR8 is essential for tumor progression following PTEN loss in the prostate." in: EMBO reports, Vol. 16, Issue 9, pp. 1219-32, (2015) (PubMed).
: "Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery." in: PLoS ONE, Vol. 7, Issue 7, pp. e40662, (2012) (PubMed).
: "NMDA mediated contextual conditioning changes miRNA expression." in: PLoS ONE, Vol. 6, Issue 9, pp. e24682, (2011) (PubMed).
: "
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DGCR8 is essential for tumor progression following PTEN loss in the prostate." in: EMBO reports, Vol. 16, Issue 9, pp. 1219-32, (2015) (PubMed).
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- Target
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
- Andere Bezeichnung
- DGCR8 (DGCR8 Produkte)
- Synonyme
- MGC78846 antikoerper, DGCR8 antikoerper, gy1 antikoerper, dgcrk6 antikoerper, C22orf12 antikoerper, DGCRK6 antikoerper, Gy1 antikoerper, pasha antikoerper, D16H22S1742E antikoerper, D16H22S788E antikoerper, D16Wis2 antikoerper, N41 antikoerper, Vo59c07 antikoerper, si:ch211-106a19.4 antikoerper, wu:fc23f08 antikoerper, wu:fc38f06 antikoerper, DGCR8 microprocessor complex subunit L homeolog antikoerper, DiGeorge syndrome critical region gene 8 antikoerper, DGCR8 microprocessor complex subunit antikoerper, DGCR8, microprocessor complex subunit antikoerper, microRNA 3618 antikoerper, dgcr8.L antikoerper, DGCR8 antikoerper, dgcr8 antikoerper, Dgcr8 antikoerper, MIR3618 antikoerper
- Hintergrund
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DGCR8 contains 2 DRBM (double-stranded RNA-binding) domains and 1 WW domain. It may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies.
Alias Symbols: C22orf12, DGCRK6, Gy1, pasha
Protein Interaction Partner: MEOX2, PYCRL, DROSHA, RAE1, MAPK1, PRMT1, ERH, CDKN2A, BMI1, SRPK2, SRPK1, CDT1, NAT10, PLEK2, RPRD2, MAPRE2, PRPF4, FLII, APP, CUL3, DDX17, HNRNPR, NCL, ILF3, HSPA8, HSPA5, HNRNPU, HNRNPH1, FUS, DHX9, DDX5,
Protein Size: 773 - Molekulargewicht
- 85 kDa
- Gen-ID
- 54487
- NCBI Accession
- NM_022720, NP_073557
- UniProt
- Q8WYQ5
- Pathways
- Regulatorische RNA Pathways
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