PIGZ Antikörper (N-Term)

Produktnummer ABIN2776579

Produktdetails anti-PIGZ Antikörper

Target: PIGZ (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z (PIGZ))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIGZ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VLWGGLSLLR VLWCLLPQTG YVHPDEFFQS PEVMAEDILG VQAARPWEFY

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against PIGZ. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PIGZ

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 579 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PIGZ Antikörper (ABIN2776579)

Taron, Colussi, Wiedman, Orlean, Taron: "Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 36083-92, (2004) (PubMed).

Details zu PIGZ

Target: PIGZ (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z (PIGZ))

Andere Bezeichnung: PIGZ (PIGZ Produkte)

Synonyme: F630022B06Rik antikoerper, GPI-MT-IV antikoerper, PIG-Z antikoerper, SMP3 antikoerper, phosphatidylinositol glycan anchor biosynthesis, class Z antikoerper, phosphatidylinositol glycan anchor biosynthesis class Z antikoerper, Pigz antikoerper, PIGZ antikoerper

Hintergrund: The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. PIGZ is a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors.The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors.
Alias Symbols: FLJ12768, GPI-MT-IV, MGC52163, SMP3, PIG-Z
Protein Size: 579

Molekulargewicht: 63 kDa

Gen-ID: 80235

NCBI Accession: NM_025163, NP_079439

UniProt: Q86VD9

Pathways: Inositol Metabolic Process