EXOSC6 Antikörper (N-Term)

Produktnummer ABIN2776613

Produktdetails anti-EXOSC6 Antikörper

Target: EXOSC6 (Exosome Component 6 (EXOSC6))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXOSC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LYAADEEEAP GTRDPTRLRP VYARAGLLSQ AKGSAYLEAG GTKVLCAVSG

Homologie: Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against EXOSC6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 272 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EXOSC6

Target: EXOSC6 (Exosome Component 6 (EXOSC6))

Andere Bezeichnung: EXOSC6 (EXOSC6 Produkte)

Synonyme: exosc6 antikoerper, RAR-gamma antikoerper, id:ibd1130 antikoerper, wu:fe17d05 antikoerper, zgc:110071 antikoerper, EAP4 antikoerper, MTR3 antikoerper, Mtr3p antikoerper, hMtr3p antikoerper, p11 antikoerper, 2610510N21Rik antikoerper, C76919 antikoerper, Mtr3 antikoerper, exosome component 6 antikoerper, EXOSC6 antikoerper, exosc6 antikoerper, CpipJ_CPIJ018071 antikoerper, Exosc6 antikoerper

Hintergrund: EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Alias Symbols: p11, EAP4, MTR3, Mtr3p, hMtr3p
Protein Interaction Partner: CEP250, DCP1B, EXOSC6, CHPF, MIF4GD, XRN1, NDUFA13, MRPL4, EXOSC1, MRPS18B, UPF2, RAB3GAP2, SKIV2L2, GSE1, EXOSC7, EXOSC8, ZFP36, TUFM, EXOSC10, MAN2C1, ESRRA, C1QBP, AICDA, DIS3L, EXOSC4, EXOSC3, CUL3, ELAVL1, HDGF, UBC, EXOSC5, DNAJC30, MOCS3, MPP6, EXO
Protein Size: 272

Molekulargewicht: 30 kDa

Gen-ID: 118460

NCBI Accession: NM_058219, NP_478126

UniProt: Q5RKV6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response