A1CF Antikörper (N-Term)

Produktnummer ABIN2776627

Produktdetails anti-A1CF Antikörper

Target: A1CF (APOBEC1 Complementation Factor (A1CF))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser A1CF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EAVCLGTCPE PEASMSTAIP GLKKGNNALQ SIILQTLLEK ENGQRKYGGP

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against A1CF. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human A1CF

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 594 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu A1CF

Target: A1CF (APOBEC1 Complementation Factor (A1CF))

Andere Bezeichnung: A1CF (A1CF Produkte)

Synonyme: ACF antikoerper, ACF64 antikoerper, ACF65 antikoerper, APOBEC1CF antikoerper, ASP antikoerper, 1810073H04Rik antikoerper, Acf antikoerper, A1cft antikoerper, Apobec-1 antikoerper, acf antikoerper, acf64 antikoerper, acf65 antikoerper, apobec1cf antikoerper, asp antikoerper, A1CF antikoerper, APOBEC1 complementation factor antikoerper, apobec1 complementation factor antikoerper, APOBEC1 complementation factor L homeolog antikoerper, A1CF antikoerper, A1cf antikoerper, a1cf antikoerper, a1cf.L antikoerper

Hintergrund: Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. A1CF has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
Alias Symbols: ACF, ACF64, ACF65, APOBEC1CF, ASP, MGC163391, RP11-564C4.2
Protein Interaction Partner: SDPR, TRAF1, REL, FHL3, KHSRP, SYNCRIP, TNPO2, CELF2, APOBEC1,
Protein Size: 594

Molekulargewicht: 65 kDa

Gen-ID: 29974

NCBI Accession: NM_138933, NP_620311

UniProt: Q9NQ94