TPM3 Antikörper (Middle Region)

Produktnummer ABIN2776646

Produktdetails anti-TPM3 Antikörper

Target: TPM3 (Tropomyosin 3 (TPM3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TPM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TEERAELAES RCREMDEQIR LMDQNLKCLS AAEEKYSQKE DKYEEEIKIL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TPM3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TPM3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 285 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TPM3 Antikörper (ABIN2776646)

Ramsey, Clarke, Roberts, Sullivan, Johnson, Liu: "An economic evaluation of atorvastatin for primary prevention of cardiovascular events in type 2 diabetes." in: PharmacoEconomics, Vol. 26, Issue 4, pp. 329-39, (2008) (PubMed).

Details zu TPM3

Target: TPM3 (Tropomyosin 3 (TPM3))

Andere Bezeichnung: TPM3 (TPM3 Produkte)

Hintergrund: TPM3 is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer.This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ41118, MGC14582, MGC3261, MGC72094, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TPMsk3, TRK, hscp30, TM5, CFTD, hTM5
Protein Interaction Partner: TLK1, MAD1L1, TRIP6, TPM3, TP53, TNNT1, VPS52, TRIM27, PBX3, MAGEA11, KIFC3, KCNE1, IFIT3, HSF2, LURAP1, WASH3P, HDDC3, FAM9C, LCA5L, C1orf216, IKBIP, SYCE1, CCDC114, CCDC102B, KXD1, CCDC146, THAP1, CCHCR1, TFPT, BLOC1S6, OIP5, UBC, MDM2, RNF2, MAGED2, MG
Protein Size: 285

Molekulargewicht: 33 kDa

Gen-ID: 7170

NCBI Accession: NM_153649, NP_705935

UniProt: P06753