CDC25B Antikörper (N-Term)

Produktnummer ABIN2776752

Produktdetails anti-CDC25B Antikörper

Target: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC25B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: TQTMHDLAGL GSETPKSQVG TLLFRSRSRL THLSLSRRAS ESSLSSESSE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CDC25B. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CDC25B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 580 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDC25B

Target: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Andere Bezeichnung: CDC25B (CDC25B Produkte)

Synonyme: CDC25B antikoerper, AI604853 antikoerper, cell division cycle 25B antikoerper, cdc25b antikoerper, CDC25B antikoerper, Cdc25b antikoerper

Hintergrund: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined.CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Protein Interaction Partner: BTRC, UBC, FBXW11, MAPK9, CDK5, CDK1, YWHAQ, MAPKAPK2, UBD, BRSK2, CDC14A, CDK2, Cdc25b, FOXM1, BRSK1, FHL3, KAT2B, MELK, YWHAE, CHEK1, AURKA, SFN, YWHAB, YWHAZ, MAPK14, CREBBP, AR, ESR1, CSNK2B, CSNK2A1, YWHAH, PGR, PHB2, KRT85, KRT35, KRT31,
Protein Size: 580

Molekulargewicht: 65 kDa

Gen-ID: 994

NCBI Accession: NM_021873, NP_068659

UniProt: P30305

Pathways: Zellzyklus, M Phase, Autophagie