Tropomyosin Antikörper (N-Term)

Produktnummer ABIN2776783

Produktdetails anti-Tropomyosin Antikörper

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio), Kaninchen, Rind (Kuh), Hund, Pferd, Schaf, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tropomyosin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: DRAEQAEADK KAAEDRSKQL EDELVSLQKK LKGTEDELDK YSEALKDAQE

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TPM1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TPM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 284 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Tropomyosin

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Andere Bezeichnung: TPM1 (TPM1 Produkte)

Hintergrund: TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
Alias Symbols: CMH3, TMSA, TPM1-alpha, CMD1Y, C15orf13, HTM-alpha
Protein Interaction Partner: GOLGA2, CAGE1, C1orf216, SYCE1, KXD1, TFPT, MAD1L1, TPM4, TP53, TNNT1, UBC, MDM2, ETFA, FOXK1, KIAA1598, PPP6R3, APPL2, CDC37, MGEA5, STUB1, ABI2, DNAJC7, HSP90B1, PARK2, LRCH3, PAN2, TGFBR1, SPTBN1, ATF2, MDC1, BRCA1, PPP4R2, SRXN1, NUDCD2, RBM15, THOC2,
Protein Size: 284

Molekulargewicht: 31 kDa

Gen-ID: 7168

NCBI Accession: NM_000366, NP_000357

UniProt: P09493

Pathways: Regulation of Actin Filament Polymerization