ASL Antikörper (N-Term)

Produktnummer ABIN2776927

Produktdetails anti-ASL Antikörper

Target: ASL (Argininosuccinate Lyase (ASL))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Hund, Ziege, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ASL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ASL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 464 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ASL Antikörper (ABIN2776927)

Trevisson, Salviati, Baldoin, Toldo, Casarin, Sacconi, Cesaro, Basso, Burlina: "Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene." in: Human mutation, Vol. 28, Issue 7, pp. 694-702, (2007) (PubMed).

Details zu ASL

Target: ASL (Argininosuccinate Lyase (ASL))

Andere Bezeichnung: ASL (ASL Produkte)

Synonyme: ASAL antikoerper, 2510006M18Rik antikoerper, zgc:63532 antikoerper, BA4879 antikoerper, PSPTO0125 antikoerper, Adl antikoerper, Asl antikoerper, argininosuccinate lyase antikoerper, argininosuccinate lyase ArgH antikoerper, adenylosuccinate lyase antikoerper, argininosuccinate lyase L homeolog antikoerper, ASL antikoerper, Asl antikoerper, asl antikoerper, argH2 antikoerper, argH antikoerper, arg7 antikoerper, CNC04420 antikoerper, STHERM_c13370 antikoerper, Adsl antikoerper, asl.L antikoerper, ARG7 antikoerper

Hintergrund: ASL is a member of the lyase 1 family. The protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in its gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency.This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: ASAL
Protein Interaction Partner: WDYHV1, ASL, GINS4, NCDN, TUFM, PDHA1, NEDD8, HK1, GDI1, BAG3, OVGP1, HMOX1, FBP1, CSNK2A2, UBC, QARS,
Protein Size: 464

Molekulargewicht: 52 kDa

Gen-ID: 435

NCBI Accession: NM_000048, NP_000039

UniProt: P04424

Pathways: Response to Growth Hormone Stimulus