TSH receptor Antikörper (C-Term)

Produktnummer ABIN310240

Produktdetails anti-TSH receptor Antikörper

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Schaf, Rind (Kuh), Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSH receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LLPLGRKSLS FETQKAPRSS

Homologie: Cow: 83%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TSHR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TSHR

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 253 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TSH receptor Antikörper (ABIN310240)

Pessina, Castillo, Sartore, Borrego, Meikle: "Semiquantitative immunohistochemical marker staining and localization in canine thyroid carcinoma and normal thyroid gland." in: Veterinary and comparative oncology, (2014) (PubMed).

Details zu TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Andere Bezeichnung: TSHR (TSHR Produkte)

Hintergrund: TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
Alias Symbols: LGR3, MGC75129, hTSHR-I, CHNG1
Protein Interaction Partner: ADRB2, SCRIB, UBC, TSHB, RABAC1, GNA13, GNA12, FLNB, TSHR, GNAQ, PIK3R1, LHCGR, JAK2, JAK1, GNAI3, GNAI2, GNAS, GNA11, GNAO1, GNAI1, HSPA5, FN1, CANX, CALR, STAT3, CALCR,
Protein Size: 253

Molekulargewicht: 28 kDa

Gen-ID: 7253

NCBI Accession: NM_001018036, NP_001018046

UniProt: Q96GT6

Pathways: Thyroid Hormone Synthesis