DAB2 Antikörper (N-Term)

Produktnummer ABIN2777076

Produktdetails anti-DAB2 Antikörper

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EVETSATNGQ PDQQAAPKAP SKKEKKKGPE KTDEYLLARF KGDGVKYKAK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DAB2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAB2

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DAB2

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Andere Bezeichnung: DAB2 (DAB2 Produkte)

Synonyme: DOC-2 antikoerper, DOC2 antikoerper, 5730435J12Rik antikoerper, AA960054 antikoerper, AI957090 antikoerper, D15Wsu122e antikoerper, D630005B22Rik antikoerper, Doc-2 antikoerper, Doc2 antikoerper, p96 antikoerper, DAB2, clathrin adaptor protein antikoerper, disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) antikoerper, Dab, mitogen-responsive phosphoprotein, homolog 2 antikoerper, disabled 2, mitogen-responsive phosphoprotein antikoerper, DAB2 antikoerper, dab2 antikoerper, Dab2 antikoerper

Hintergrund: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: Fcho2, CPSF7, SMURF2, YLPM1, C14orf166, ACOT9, CPSF6, SF3B2, MALT1, HSPH1, SEC23B, SEC24B, NUP155, CDC16, TRIO, TFAP2A, AURKA, PYCR1, PRDX1, MYO6, HSPA1B, HNRNPL, GRB2, FN1, CLTC, AP2M1, CFTR, CCNT1, ACTB, AHCY, AP2B1, AP2A2, AP2A1, DYT10, ATXN1L, SH3KBP1
Protein Size: 552

Molekulargewicht: 60 kDa

Gen-ID: 1601

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process