E2F4 Antikörper (C-Term)

Produktnummer ABIN2777218

Produktdetails anti-E2F4 Antikörper

Target: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Kaninchen, Hund, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser E2F4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: SSELLEELMS SEVFAPLLRL SPPPGDHDYI YNLDESEGVC DLFDVPVLNL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against E2F4. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human E2F4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 413 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu E2F4

Target: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Andere Bezeichnung: E2F4 (E2F4 Produkte)

Synonyme: E2F-4 antikoerper, 2010111M04Rik antikoerper, AI427446 antikoerper, E2F4 antikoerper, e2f-4 antikoerper, fb72f07 antikoerper, wu:fb72f07 antikoerper, wu:fe05f06 antikoerper, zgc:63815 antikoerper, E2F transcription factor 4 antikoerper, E2F transcription factor 4 S homeolog antikoerper, E2F4 antikoerper, E2f4 antikoerper, e2f4.S antikoerper, e2f4 antikoerper

Hintergrund: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Alias Symbols: E2F-4
Protein Interaction Partner: RBL2, TFDP1, RBL1, RB1, XPO1, PCM1, HDAC1, POLR1D, CHMP2A, AP3S2, TRIM28, LIN9, ARID3A, NCOR2, HDAC3, AR, CEBPA, LIN54, LIN37, UBC, ATAD2, SIN3A, ASH2L, HCFC1, TRRAP, KAT2A, ID2, E2F1, KMT2A, ID3, SMAD3, NOLC1, TFDP2, NDN, SMAD2, BRCA1, RYBP, RNF144A, FHL
Protein Size: 413

Molekulargewicht: 44 kDa

Gen-ID: 1874

NCBI Accession: NM_001950, NP_001941

UniProt: Q16254

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size