POU1F1 Antikörper (N-Term)

Produktnummer ABIN2777284

Produktdetails anti-POU1F1 Antikörper

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Ziege, Pferd, Kaninchen, Schaf, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POU1F1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TPCLYKFPDH TLSHGFPPIH QPLLAEDPTA ADFKQELRRK SKLVEEPIDM

Homologie: Cow: 100%, Dog: 92%, Goat: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 86%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against POU1F1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human POU1F1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 291 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-POU1F1 Antikörper (ABIN2777284)

Dattani: "Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene." in: Journal of pediatric endocrinology & metabolism : JPEM, Vol. 16, Issue 9, pp. 1207-9, (2004) (PubMed).

Details zu POU1F1

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Andere Bezeichnung: POU1F1 (POU1F1 Produkte)

Synonyme: CPHD1 antikoerper, GHF-1 antikoerper, PIT1 antikoerper, POU1F1a antikoerper, Pit-1 antikoerper, Hmp1 antikoerper, Pit1 antikoerper, Pit1-rs1 antikoerper, dw antikoerper, dwarf antikoerper, GHF1 antikoerper, GHF1A antikoerper, PIT1Z antikoerper, PIT-1 antikoerper, Pit-1* antikoerper, pit1 antikoerper, pit-1 antikoerper, POU class 1 homeobox 1 antikoerper, POU domain, class 1, transcription factor 1 antikoerper, POU1F1 antikoerper, Pou1f1 antikoerper, pou1f1 antikoerper

Hintergrund: PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
Alias Symbols: PIT1, CPHD1, GHF-1, Pit-1, POU1F1a
Protein Interaction Partner: CEBPD, NCOR1, CREBBP, MED1, GATA2, NR1I3, NR1I2, PITX1, JUN, ETS1, NR3C1, VDR, PPARG, PPARA,
Protein Size: 291

Molekulargewicht: 33 kDa

Gen-ID: 5449

NCBI Accession: NM_000306, NP_000297

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process