HDAC6 Antikörper (N-Term)

Produktnummer ABIN2777306

Produktdetails anti-HDAC6 Antikörper

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Meerschweinchen, Pferd, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Sequenz: VGLQGMDLNL EAEALAGTGL VLDEQLNEFH CLWDDSFPEG PERLHAIKEQ

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HDAC6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HDAC6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1215 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Andere Bezeichnung: HDAC6 (HDAC6 Produkte)

Hintergrund: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Alias Symbols: HD6, JM21
Protein Interaction Partner: HSP90B1, ACTB, UBC, TRIM50, MYH10, DYNC1H1, DDIT3, ELAVL1, MAPK3, MAPK1, RUNX2, TUBA1B, SUMO1, RANBP9, NEDD8, ADRB2, ATXN3, MEF2B, SQSTM1, HSP90AA1, RASSF2, SLMAP, SAV1, CTTNBP2NL, BAG3, SETD8, TUBB, HSPA8, HSPA6, HSPA5, HSPA4, HSPA2, HSPA1L, DNAJA1, ETV6
Protein Size: 1215

Molekulargewicht: 131 kDa, 17 kDa

Gen-ID: 10013

NCBI Accession: NM_006044

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling