COPS5 Antikörper (N-Term)

Produktnummer ABIN2777332

Produktdetails anti-COPS5 Antikörper

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Pferd, Kaninchen, Meerschweinchen, Hund, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AASGSGMAQK TWELANNMQE AQSIDEIYKY DKKQQQEILA AKPWTKDHHY

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against COPS5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human COPS5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 334 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Andere Bezeichnung: COPS5 (COPS5 Produkte)

Synonyme: BcDNA.LD14392 antikoerper, BcDNA:LD14392 antikoerper, CG14884 antikoerper, CH5 antikoerper, CSN-5 antikoerper, Csn5 antikoerper, DCH5 antikoerper, Dch5 antikoerper, Dmel\\CG14884 antikoerper, JAB1 antikoerper, JAB1/CSN5 antikoerper, Jab1 antikoerper, JadBp antikoerper, csn5 antikoerper, dch5 antikoerper, jab1/csn5 antikoerper, l(3)89Cf antikoerper, l(3)L4032 antikoerper, l(3)M203 antikoerper, quo antikoerper, COPS5 antikoerper, MGC76063 antikoerper, AI303502 antikoerper, CSN5 antikoerper, Mov34 antikoerper, Sgn5 antikoerper, zgc:73130 antikoerper, MOV-34 antikoerper, SGN5 antikoerper, COP9 signalosome subunit 5 antikoerper, COP9 signalosome complex subunit 5 antikoerper, COP9 signalosome subunit 5 S homeolog antikoerper, CSN5 antikoerper, COPS5 antikoerper, cops5 antikoerper, CpipJ_CPIJ012314 antikoerper, Bm1_46585 antikoerper, VDBG_06932 antikoerper, LOAG_01443 antikoerper, csn5 antikoerper, Cops5 antikoerper, cops5.S antikoerper, csn-5 antikoerper

Hintergrund: COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CSN5, JAB1, MGC3149, MOV-34, SGN5
Protein Interaction Partner: COPS6, UBC, CUL1, NEDD8, PTGS2, GPS1, LRP1, RANBP9, APP, SIAH1, BACE1, CTNNB1, COPS5, STAT3, CREB3, COPS4, SART3, COPS3, EPB41L1, CAST, KIF5B, PDLIM7, SMAD4, FBXO6, COPS2, TYK2, CDK2, CENPW, CENPT, FBXW4, MYEOV2, COPS8, CHUK, IKBKB, DTL, CD93, DDO, SMAD2,
Protein Size: 334

Molekulargewicht: 37 kDa

Gen-ID: 10987

NCBI Accession: NM_006837, NP_006828

UniProt: Q92905

Pathways: Zellzyklus