SNF8 Antikörper (N-Term)

Produktnummer ABIN2777341

Produktdetails anti-SNF8 Antikörper

Target: SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNF8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MHRRGVGAGA IAKKKLAEAK YKERGTVLAE DQLAQMSKQL DMFKTNLEEF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SNF8. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EAP30

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 258 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SNF8

Target: SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))

Andere Bezeichnung: EAP30 (SNF8 Produkte)

Synonyme: d11moh34 antikoerper, vps22 antikoerper, Dot3 antikoerper, EAP30 antikoerper, VPS22 antikoerper, D11moh34 antikoerper, RGD1310144 antikoerper, D11Moh34 antikoerper, D11MOH34 antikoerper, zgc:101578 antikoerper, SNF8, ESCRT-II complex subunit antikoerper, eap30 subunit of ell complex, putative antikoerper, EAP30 subunit of ELL complex antikoerper, SNF8, ESCRT-II complex subunit S homeolog antikoerper, SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) antikoerper, snf8 antikoerper, TA17290 antikoerper, TVAG_107410 antikoerper, Bm1_05145 antikoerper, SNF8 antikoerper, Snf8 antikoerper, snf8.S antikoerper

Hintergrund: ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL, MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741], Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].
Alias Symbols: Dot3, EAP30, VPS22
Protein Interaction Partner: GOLGA2, VPS25, TRIM54, VAC14, UBC, BCAT1, SUV39H2, ACBD3, DUS3L, WDR12, PRMT6, RPUSD2, KDM1A, EFTUD2, TTC1, HARS, GTF2F1, GTF2E1, ELL, RBP1, MCM2, ADORA1, METTL14, NUDCD3, RILP, VPS36, CHMP6, VPS28, SNF8, TSG101, VPS20, NIF3L1, DVL2,
Protein Size: 258

Molekulargewicht: 29 kDa

Gen-ID: 11267

NCBI Accession: NM_007241, NP_009172

UniProt: Q96H20