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KDM4C Antikörper (C-Term)

KDM4C Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Schwein WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2777688
  • Target Alle KDM4C Antikörper anzeigen
    KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))
    Bindungsspezifität
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Schwein
    Wirt
    • 37
    • 2
    Kaninchen
    Klonalität
    • 37
    • 2
    Polyklonal
    Konjugat
    • 19
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KDM4C Antikörper ist unkonjugiert
    Applikation
    • 26
    • 16
    • 9
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    CLCNLRGGAL KQTKNNKWAH VMCAVAVPEV RFTNVPERTQ IDVGRIPLQR
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against JMJD2C. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human JMJD2C
    Top Product
    Discover our top product KDM4C Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 813 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lu, Ward, Kapoor, Rohle, Turcan, Abdel-Wahab, Edwards, Khanin, Figueroa, Melnick, Wellen, ORourke, Berger, Chan, Levine, Mellinghoff, Thompson: "IDH mutation impairs histone demethylation and results in a block to cell differentiation." in: Nature, Vol. 483, Issue 7390, pp. 474-8, (2012) (PubMed).

  • Target
    KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))
    Andere Bezeichnung
    JMJD2C (KDM4C Produkte)
    Hintergrund
    JMJD2C is a member of the Jumonji domain 2 (JMJD2) family. It contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.
    Alias Symbols: FLJ25949, GASC1, JHDM3C, JMJD2C, KIAA0780, bA146B14.1
    Protein Interaction Partner: UBC, HIST2H3C, HDAC3, PPARG, HDAC1, H3F3A, HIST1H3A, KDM4C, KDM4A,
    Protein Size: 813
    Molekulargewicht
    92 kDa
    Gen-ID
    23081
    NCBI Accession
    NM_001146695, NP_001140167
    UniProt
    F5H347
    Pathways
    Nuclear Hormone Receptor Binding, Warburg Effekt
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