PCCA Antikörper (N-Term)

Produktnummer ABIN2777736

Produktdetails anti-PCCA Antikörper

Target: PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Hund, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LYYSRQCLMV SRNLGSVGYD PNEKTFDKIL VANRGEIACR VIRTCKKMGI

Homologie: Cow: 86%, Dog: 86%, Horse: 83%, Human: 100%, Mouse: 77%, Pig: 86%, Rabbit: 86%, Rat: 86%, Zebrafish: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against PCCA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCCA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 728 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PCCA Antikörper (ABIN2777736)

Rincón, Aguado, Desviat, Sánchez-Alcudia, Ugarte, Pérez: "Propionic and methylmalonic acidemia: antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA." in: American journal of human genetics, Vol. 81, Issue 6, pp. 1262-70, (2011) (PubMed).

Details zu PCCA

Target: PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))

Andere Bezeichnung: PCCA (PCCA Produkte)

Synonyme: pcca antikoerper, zgc:66359 antikoerper, C79630 antikoerper, wu:fb92g02 antikoerper, zgc:100925 antikoerper, propionyl-CoA carboxylase alpha subunit antikoerper, propionyl-COA carboxylase alpha chain, mitochondrial antikoerper, propionyl-CoA carboxylase alpha chain antikoerper, zinc finger CCCH-type containing 13 antikoerper, propionyl-Coenzyme A carboxylase, alpha polypeptide antikoerper, propionyl CoA carboxylase, alpha polypeptide antikoerper, propionyl-CoA carboxylase alpha subunit L homeolog antikoerper, PCCA antikoerper, Pcca antikoerper, BMEI0800 antikoerper, pccA antikoerper, NRI_0781 antikoerper, zc3h13 antikoerper, pcca antikoerper, pcca.L antikoerper

Hintergrund: PCCA is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA is the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia.The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: -
Protein Interaction Partner: HUWE1, PARK2, IFIT1, UBE2N, UBC, EBNA-LP, PCCB,
Protein Size: 728

Molekulargewicht: 75 kDa

Gen-ID: 5095

NCBI Accession: NM_000282, NP_000273

UniProt: Q8WXQ7

Pathways: Monocarboxylic Acid Catabolic Process