ATXN7 Antikörper (Middle Region)

Produktnummer ABIN2777891

Produktdetails anti-ATXN7 Antikörper

Target: ATXN7 (Ataxin 7 (ATXN7))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Meerschweinchen, Pferd, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATXN7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TRSLTCKTHS LTQRRAVQGR RKRFDVLLAE HKNKTREKEL IRHPDSQQPP

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 92%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against ATXN7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATXN7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 892 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ATXN7 Antikörper (ABIN2777891)

Mu, Lin, Chen, Sung, Bai, Jow: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." in: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).

Details zu ATXN7

Target: ATXN7 (Ataxin 7 (ATXN7))

Andere Bezeichnung: ATXN7 (ATXN7 Produkte)

Synonyme: MGC82940 antikoerper, ADCAII antikoerper, OPCA3 antikoerper, SCA7 antikoerper, A430107N12Rik antikoerper, AI627028 antikoerper, Sca7 antikoerper, ataxin-7 antikoerper, RGD1562692 antikoerper, ataxin 7 L homeolog antikoerper, ataxin 7 antikoerper, atxn7.L antikoerper, atxn7 antikoerper, ATXN7 antikoerper, Atxn7 antikoerper

Hintergrund: ATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Alias Symbols: ADCAII, OPCA3, SCA7
Protein Interaction Partner: VCP, USP22, PICK1, TP53BP2, RAD23A, ATXN7L3, ENY2, PIAS1, SUMO1, UBE2I, SUMO2, KAT2A, AGRN, LRSAM1, ADAM33, CEP70, COG6, TRIM54, CEP72, RNF31, PPP1R12C, CRIM1, TXNDC11, EFEMP2, UBQLN2, CARD10, NOC2L, NUP62, MPRIP, SPRY1, GPRASP1, PNMA1, RABEP1, KALRN, LTB
Protein Size: 892

Molekulargewicht: 95 kDa

Gen-ID: 6314

NCBI Accession: NM_000333, NP_000324

UniProt: O15265