SUPT5H Antikörper (Middle Region)

Produktnummer ABIN2778245

Produktdetails anti-SUPT5H Antikörper

Target: SUPT5H (Transcription Elongation Factor SPT5 (SUPT5H))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Hund, Rind (Kuh), Ratte, Kaninchen, Pferd, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUPT5H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FEDQPEGIDL EVVTESTGKE REHNFQPGDN VEVCEGELIN LQGKILSVDG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SUPT5H. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SUPT5H

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1087 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SUPT5H Antikörper (ABIN2778245)

Ueki, Lin, Senoo, Ebihara, Agata, Onji, Saheki, Kawai, Mukherjee, Reichenberger, Olsen: "Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice." in: Cell, Vol. 128, Issue 1, pp. 71-83, (2007) (PubMed).

Amir-Zilberstein, Ainbinder, Toube, Yamaguchi, Handa, Dikstein: "Differential regulation of NF-kappaB by elongation factors is determined by core promoter type." in: Molecular and cellular biology, Vol. 27, Issue 14, pp. 5246-59, (2007) (PubMed).

Details zu SUPT5H

Target: SUPT5H (Transcription Elongation Factor SPT5 (SUPT5H))

Andere Bezeichnung: SUPT5H (SUPT5H Produkte)

Hintergrund: SUPT5H and its binding partner regulate transcriptional elongation by RNA polymerase II. SPT4 and SPT5 are involved in both 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB)-mediated transcriptional inhibition and the activation of transcriptional elongation by the human immunodeficiency virus type 1 (HIV-1) Tat protein.
Alias Symbols: FLJ34157, SPT5, SPT5H, Tat-CT1
Protein Interaction Partner: POLR2A, BRCA1, UBC, RNF2, SAMHD1, GANAB, SWAP70, PAICS, CARM1, FARSB, SEC24C, RANBP3, CSDE1, SF1, SET, PLOD2, MSH2, MSH6, GART, XRCC6, ATP6V1B2, SOX2, LMNA, CDK9, CCNT2, CCNT1, tat, NSMF, FN1, CSNK2A1, SIK1, ZNF512B, LMAN2, ZFYVE9, SNX4, SUPT4H1, POLR2C,
Protein Size: 1087

Molekulargewicht: 121 kDa

Gen-ID: 6829

NCBI Accession: NM_003169, NP_003160

UniProt: O00267