TRIM21 Antikörper (N-Term)

Produktnummer ABIN2778305

Produktdetails anti-TRIM21 Antikörper

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GELRRKQELA EKLEVEIAIK RADWKKTVET QKSRIHAEFV QQKNFLVEEE

Homologie: Dog: 77%, Guinea Pig: 92%, Human: 100%, Mouse: 83%, Rabbit: 85%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against TRIM21. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM21

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 475 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Andere Bezeichnung: TRIM21 (TRIM21 Produkte)

Hintergrund: TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM21 is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: RNF81, RO52, SSA, SSA1
Protein Interaction Partner: TRIM39, IGHV4-31, TXN2, GRAP, UBE2I, TRIM21, IGHG1, USP15, HAUS2, UBE2D2, UBC, FBXO6, UBD, NPM1, PAN2, ROR1, NOS2, MYC, IQCB1, USP2, VCP, USP4, CDC34, CBL, UBC4, UBE2C, UBE2L3, UBE2H, UBE2D1, TROVE2, TRIM27, MNAT1, FCGR2A, CD52, DCP2, ZFPM1, TRIM5, TRIM8,
Protein Size: 475

Molekulargewicht: 54 kDa

Gen-ID: 6737

NCBI Accession: NM_003141, NP_003132

UniProt: P19474