PRMT2 Antikörper (N-Term)
(4 Referenzen)-
- Target Alle PRMT2 Antikörper anzeigen
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Schwein, Pferd, Meerschweinchen, Kaninchen, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PRMT2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL
- Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot and immunohistochemistry.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
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anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-300) antibody
PRMT2 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 22-53) antibodyPRMT2 Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-300) antibodyPRMT2 Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 22-53), (N-Term) antibodyPRMT2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB0027 unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-433) antibodyPRMT2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) antibodyPRMT2 Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 344-375), (C-Term) antibodyPRMT2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB0191 unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibodyPRMT2 Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibodyPRMT2 Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Fledermaus, Hamster, Affe WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibodyPRMT2 Reaktivität: Human, Ratte, Maus WB, IHC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 433 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo." in: Cell reports, Vol. 5, Issue 3, pp. 687-701, (2013) (PubMed).
: "Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma." in: The FEBS journal, Vol. 279, Issue 2, pp. 316-35, (2012) (PubMed).
: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).
: "Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer." in: Gene, Vol. 487, Issue 1, pp. 1-9, (2011) (PubMed).
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: "Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo." in: Cell reports, Vol. 5, Issue 3, pp. 687-701, (2013) (PubMed).
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- Target
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Andere Bezeichnung
- PRMT2 (PRMT2 Produkte)
- Synonyme
- PRMT2 antikoerper, DKFZp459N1919 antikoerper, HRMT1L1 antikoerper, Hrmt1l1 antikoerper, AI504737 antikoerper, protein arginine methyltransferase 2 antikoerper, protein arginine methyltransferase 2 L homeolog antikoerper, protein arginine N-methyltransferase 2 antikoerper, PRMT2 antikoerper, Prmt2 antikoerper, prmt2.L antikoerper
- Hintergrund
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The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Alias Symbols: HRMT1L1
Protein Interaction Partner: FIP1L1, SPAG8, RIPK2, BAG6, RB1, HNRNPA1, E2F1, UBC, PSMB3, HHV8GK18_gp81, CPSF7, DMRTB1, HNRNPUL1, PRMT2, THRB, PGR, NCOA6, NCOA1, ESR2, RXRA, PRRC2A, ESR1, PPARG, RARA,
Protein Size: 433 - Molekulargewicht
- 48 kDa
- Gen-ID
- 3275
- NCBI Accession
- NM_001535, NP_001526
- UniProt
- P55345
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
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