Splicing factor U2AF 26 kDa subunit (U2AF1L4) (N-Term) Antikörper

Produktnummer ABIN2778747

Produktdetails

Target: Splicing factor U2AF 26 kDa subunit (U2AF1L4)

Bindungsspezifität: N-Term

Reaktivität: Human, Hund, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KIGVCRHGDR CSRLHNKPTF SQTIVLLNLY RNPQNTAQTA DGSHCHVSDV

Homologie: Cow: 100%, Dog: 100%, Goat: 79%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against U2AF1L4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human U2AF1L4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Antigendetails

Target: Splicing factor U2AF 26 kDa subunit (U2AF1L4)

Andere Bezeichnung: U2AF1L4 (U2AF1L4 Produkte)

Synonyme: U2 small nuclear RNA auxiliary factor 1-like protein 3 antikoerper, U2AF1-RS3 antikoerper, U2AF1-like 4 antikoerper, U2AF1-like protein 3 antikoerper, U2AF1L3 antikoerper, U2AF1L3V1 antikoerper, U2AF1RS3 antikoerper, U2af26 antikoerper, AA407033 antikoerper, AF419339 antikoerper, AI451269 antikoerper, AW553050 antikoerper, TMEM149 antikoerper, U2 small nuclear RNA auxiliary factor 1 like 4 antikoerper, U2 small nuclear RNA auxiliary factor 1-like 4 antikoerper, U2AF1L4 antikoerper, U2af1l4 antikoerper

Hintergrund: U2AF1L4 is a RNA-binding protein that function as a pre-mRNA splicing factor. It plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It acts by enhancing the binding of U2AF2 to weak pyrimidine tracts and also participates in the regulation of alternative pre-mRNA splicing. It activates exon 5 skipping of PTPRC during T-cell activation, an event reversed by GFI1. U2AF1L4 binds to RNA at the AG dinucleotide at the 3'-splice site.
Protein Interaction Partner: MDM2, SUZ12, UBC, ELAVL1, GIGYF2,
Protein Size: 220

Molekulargewicht: 24 kDa

Gen-ID: 199746

UniProt: Q8WU68