HNRNPA1 Antikörper (N-Term)

Produktnummer ABIN2778789

Produktdetails anti-HNRNPA1 Antikörper

Target: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNRNPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HNRPA1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 320 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HNRNPA1 Antikörper (ABIN2778789)

Li, Wang, Ding, Xu, Zhao, Li, Li, Xia, Su, Chen, Fang, Shao, Zhang: "Aptamer BC15 against heterogeneous nuclear ribonucleoprotein A1 has potential value in diagnosis and therapy of hepatocarcinoma." in: Nucleic acid therapeutics, Vol. 22, Issue 6, pp. 391-8, (2012) (PubMed).

Stark, Bram, Akerman, Mandel-Gutfreund, Assaraf: "Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance." in: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3741-54, (2011) (PubMed).

Gonen, Assaraf: "The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 33602-13, (2010) (PubMed).

Li, Xu, Ding, Huang, Cao, Yang, Li, Xie, Meng, Li, Zhao, Shen, Shao: "Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX." in: The Journal of pathology, Vol. 218, Issue 3, pp. 327-36, (2009) (PubMed).

Details zu HNRNPA1

Target: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Andere Bezeichnung: HNRPA1 (HNRNPA1 Produkte)

Synonyme: HNRPA1 antikoerper, HNRPA1L3 antikoerper, hnRNP A1 antikoerper, hnRNP-A1 antikoerper, hnrpa1 antikoerper, TPT1P antikoerper, HNRNPA1 antikoerper, D15Ertd119e antikoerper, Hdp antikoerper, Hnrpa1 antikoerper, hnrnp-A1 antikoerper, ROA1 antikoerper, zgc:66127 antikoerper, heterogeneous nuclear ribonucleoprotein A1 antikoerper, heterogeneous nuclear ribonucleoprotein A1b antikoerper, Heterogeneous nuclear ribonucleoprotein A1 antikoerper, heterogeneous nuclear ribonucleoprotein A1 S homeolog antikoerper, ribonucleoprotein A1a antikoerper, heterogeneous nuclear ribonucleoprotein A1-like antikoerper, heterogeneous nuclear ribonucleoprotein A1a antikoerper, HNRNPA1 antikoerper, hnrnpa1b antikoerper, LOC100101226 antikoerper, roa1 antikoerper, Hnrnpa1 antikoerper, hnrnpa1.S antikoerper, hnrnpa1 antikoerper, LOC100359118 antikoerper, hnrnpa1a antikoerper

Hintergrund: HNRPA1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). HNRPA1 has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. HNRPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.
Alias Symbols: HNRPA1, HNRPA1L3, hnRNP A1, hnRNP-A1
Protein Interaction Partner: UBC, TP53, PSMD9, TUBGCP3, NEDD1, AURKB, AURKA, STAU1, IVNS1ABP, TNF, PSMB4, MDM2, CHUK, RPA3, RPA2, RPA1, ASB2, ERG, EED, RNF2, rev, IQGAP1, HIST1H2AB, AIMP2, RPL38, RPL27A, QARS, DHX9, CCAR2, ZC3HC1, HNRNPU, PARK2, FBXO6, TARDBP, YWHAQ, SRPK1, XRN1, CSF
Protein Size: 320

Molekulargewicht: 35 kDa

Gen-ID: 3178

NCBI Accession: NM_002136, NP_002127

UniProt: Q6IPF2