ISG20 Antikörper (N-Term)

Produktnummer ABIN2778795

Produktdetails anti-ISG20 Antikörper

Target: ISG20 (Interferon Stimulated Exonuclease Gene 20kDa (ISG20))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Hund, Pferd, Schwein, Rind (Kuh), Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ISG20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GAVLYDKFIR PEGEITDYRT RVSGVTPQHM VGATPFAVAR LEILQLLKGK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against ISG20. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ISG20

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 181 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ISG20 Antikörper (ABIN2778795)

Zahoor, Xue, Sato, Murakami, Takeshima, Aida: "HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages." in: PLoS ONE, Vol. 9, Issue 8, pp. e106418, (2014) (PubMed).

Horio, Murai, Inoue, Hamasaki, Tanaka, Ohgi: "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease." in: FEBS letters, Vol. 577, Issue 1-2, pp. 111-6, (2004) (PubMed).

Details zu ISG20

Target: ISG20 (Interferon Stimulated Exonuclease Gene 20kDa (ISG20))

Andere Bezeichnung: ISG20 (ISG20 Produkte)

Hintergrund: ISG20 belongs to the the exonuclease superfamily. It is exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. It degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. It is involved in the antiviral function of IFN against RNA viruses.
Alias Symbols: CD25, HEM45
Protein Interaction Partner: UBC,
Protein Size: 181

Molekulargewicht: 20 kDa

Gen-ID: 3669

NCBI Accession: NM_002201, NP_002192

UniProt: Q96AZ6