NXF1 Antikörper (N-Term)

Produktnummer ABIN2778977

Produktdetails anti-NXF1 Antikörper

Target: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NXF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS

Homologie: Cow: 92%, Dog: 83%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NXF1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NXF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 619 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NXF1

Target: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Andere Bezeichnung: NXF1 (NXF1 Produkte)

Synonyme: im:7156527 antikoerper, wu:fc12d06 antikoerper, MGC82224 antikoerper, NXF1 antikoerper, tap antikoerper, mex67 antikoerper, MEX67 antikoerper, TAP antikoerper, Mex67 antikoerper, Mvb1 antikoerper, Tap antikoerper, Mex67h antikoerper, nuclear RNA export factor 1 antikoerper, nuclear RNA export factor 1 S homeolog antikoerper, Nuclear RNA export factor 1 antikoerper, nxf1 antikoerper, nxf1.S antikoerper, NXF1 antikoerper, LOC100113601 antikoerper, Tsp_03999 antikoerper, Nxf1 antikoerper, nxf-1 antikoerper

Hintergrund: NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.
Alias Symbols: TAP, MEX67
Protein Interaction Partner: KRT40, TIFA, GFAP, LDOC1, NUP62, MID2, TP53BP2, DVL3, SUMO2, UBC, SUZ12, EED, BMI1, TARDBP, NXT1, NUP98, RANBP2, ESRRA, KCTD5, TRA2A, SGTA, TRA2B, SRSF1, RAD51, ZBED2, CSNK2A1, EIF2A, ILF3, HNRNPC, HNRNPK, DHX15, DHX9, DDB1, DDX19A, LUC7L3, HP1BP3, RBMX,
Protein Size: 619

Molekulargewicht: 68 kDa

Gen-ID: 10482

NCBI Accession: NM_006362, NP_006353

UniProt: Q9UBU9