PRPF8 Antikörper (N-Term)

Produktnummer ABIN2778986

Der Kaninchen Polyklonal Anti-PRPF8-Antikörper wurde für WB validiert. Er ist geeignet, PRPF8 in Proben von Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen zu detektieren.

Kurzübersicht für PRPF8 Antikörper (N-Term) (ABIN2778986)

Target: PRPF8 (PRP8 Pre-mRNA Processing Factor 8 (PRPF8))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRPF8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRPF8 Antikörper

Bindungsspezifität: N-Term

Sequenz: SHRHSVKSQE PLPDDDEEFE LPEFVEPFLK DTPLYTDNTA NGIALLWAPR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PRPF8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRPF8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2335 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PRPF8

Target: PRPF8 (PRP8 Pre-mRNA Processing Factor 8 (PRPF8))

Andere Bezeichnung: PRPF8

Hintergrund: Pre-mRNA splicing occurs in 2 sequential transesterification steps. PRPF8 is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. The gene encoding PRPF8 is a candidate gene for autosomal dominant retinitis pigmentosa.Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HPRP8, PRP8, PRPC8, RP13
Protein Interaction Partner: SNRNP200, PRPF8, EFTUD2, UBC, CDKN1A, SUMO2, SUMO3, STAU1, LGR4, NEDD8, ERG, ASB15, WWOX, RPA3, RPA2, RPA1, EED, RNF2, SUZ12, rev, PIN1, NEDD4, FBXO6, PRPF4B, UBD, IGSF8, ICAM1, SND1, SF3B2, SLU7, ZNF830, WDR83, PRPF19, GPKOW, FN1, BCAS2, SF3B4, RBM5, VCA
Protein Size: 2335

Molekulargewicht: 273 kDa

Gen-ID: 10594

NCBI Accession: NM_006445, NP_006436

UniProt: Q6P2Q9