CELF2 Antikörper (N-Term)

Produktnummer ABIN2779001

Produktdetails anti-CELF2 Antikörper

Target: CELF2 (CUGBP, Elav-Like Family Member 2 (CELF2))

Bindungsspezifität: N-Term

Reaktivität: Human, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CELF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: TSAFKLDFLP DMMVEGRLLV PDRINGTANK MNGALDHSDQ PDPDAIKMFV

Homologie: Cow: 100%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CUGBP2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CUGBP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 521 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CELF2 Antikörper (ABIN2779001)

Subramaniam, Natarajan, Ramalingam, Ramachandran, May, Queimado, Houchen, Anant: "Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 4, pp. G1025-32, (2008) (PubMed).

Details zu CELF2

Target: CELF2 (CUGBP, Elav-Like Family Member 2 (CELF2))

Andere Bezeichnung: CUGBP2 (CELF2 Produkte)

Hintergrund: CUGBP2 is a member of the CELF/BRUNOL protein family, which contains two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of CUGBP2 family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. If alternative splicing were to result, multiple transcript variants encoding different isoforms would appear.Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: BRUNOL3, ETR-3, NAPOR, ETR3, CUGBP2
Protein Interaction Partner: PTGS2, ELAVL1, UBC, FN1, APP, PCBP1, A1CF, APOBEC1, Apob,
Protein Size: 521

Molekulargewicht: 56 kDa

Gen-ID: 10659

NCBI Accession: NM_006561, NP_006552

Pathways: Ribonucleoprotein Complex Subunit Organization