IRAK3 Antikörper (C-Term)

Produktnummer ABIN184022

Produktdetails anti-IRAK3 Antikörper

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRAK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE DDESQNNNLL

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against IRAK3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IRAK3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 596 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu IRAK3

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Andere Bezeichnung: IRAK3 (IRAK3 Produkte)

Hintergrund: IRAK3 contains 1 protein kinase domain and 1 death domain and belongs to the Ser/Thr protein kinase family, Pelle subfamily. It inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Alias Symbols: ASRT5, IRAKM
Protein Interaction Partner: CDCA5, NSA2, LDB1, NTRK3, NONO, HSP90AA1, HOXB7, FOLR1, ECM1, COPB1, CD14, ATP6V0B, ADH1B, IRAK1, UBC, IRAK4, IRAK2, TICAM2, IRAK3, TRAF6, MYD88,
Protein Size: 596

Molekulargewicht: 66 kDa

Gen-ID: 11213

NCBI Accession: NM_007199, NP_009130

UniProt: Q9Y616

Pathways: TLR Signalweg, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades