PUF60 Antikörper (C-Term)

Produktnummer ABIN2779054

Produktdetails anti-PUF60 Antikörper

Target: PUF60 (Poly-U Binding Splicing Factor 60KDa (PUF60))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PUF60 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: EIIVKIFVEF SIASETHKAI QALNGRWFAG RKVVAEVYDQ ERFDNSDLSA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PUF60. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PUF60

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 542 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PUF60

Target: PUF60 (Poly-U Binding Splicing Factor 60KDa (PUF60))

Andere Bezeichnung: PUF60 (PUF60 Produkte)

Synonyme: FIR antikoerper, RoBPI antikoerper, SIAHBP1 antikoerper, fc21a05 antikoerper, wu:fc21a05 antikoerper, wu:fi43a08 antikoerper, 2410104I19Rik antikoerper, 2810454F19Rik antikoerper, Siahbp1 antikoerper, fe37c05 antikoerper, repressor antikoerper, si:ch211-12p8.2 antikoerper, si:zc12p8.2 antikoerper, wu:fb33e11 antikoerper, wu:fe37c05 antikoerper, zgc:86806 antikoerper, poly(U) binding splicing factor 60 antikoerper, poly-U binding splicing factor a antikoerper, poly-U binding splicing factor 60 antikoerper, poly-U binding splicing factor b antikoerper, PUF60 antikoerper, puf60a antikoerper, Puf60 antikoerper, puf60b antikoerper

Hintergrund: PUF60 is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription.The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
Alias Symbols: FIR, FLJ31379, RoBPI, SIAHBP1
Protein Interaction Partner: ZG16, ARL8A, LOH12CR1, KIAA1683, MED28, QRICH1, UBE2I, SIAH1, SRSF11, SAP30BP, UPF2, KIAA0907, PUF60, U2AF2, SDCBP, RAD23B, CCNC, SUMO2, SUMO3, CDKN1A, UBC, ERG, EED, H3F3A, FAM129B, VPS29, FAF1, PAPOLA, NUDC, HIRIP3, ZYX, UGP2, TARS, TROVE2, PPM1G, PPP1R
Protein Size: 542

Molekulargewicht: 58 kDa

Gen-ID: 22827

NCBI Accession: NM_014281, NP_055096