TCF7L1 Antikörper (N-Term)

Produktnummer ABIN2779272

Produktdetails anti-TCF7L1 Antikörper

Target: TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCF7L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: NDELIPFQDE GGEEQEPSSD SASAQRDLDE VKSSLVNESE NQSSSSDSEA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TCF7L1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 588 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TCF7L1

Target: TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1))

Andere Bezeichnung: TCF7L1 (TCF7L1 Produkte)

Synonyme: TCF-3 antikoerper, TCF3 antikoerper, Tcf-3 antikoerper, Tcf3 antikoerper, bHLHb21 antikoerper, tcf3c antikoerper, tcf3d antikoerper, xtcf3 antikoerper, XTCF-3 antikoerper, tcf7l1 antikoerper, tcf3b antikoerper, TCF-3-A antikoerper, tcf-3 antikoerper, tcf3 antikoerper, tcf3a antikoerper, zTcf-3 antikoerper, transcription factor 7 like 1 antikoerper, transcription factor 7 like 1 (T cell specific, HMG box) antikoerper, transcription factor 7 like 1 L homeolog antikoerper, transcription factor 7 like 1 S homeolog antikoerper, transcription factor 7 like 1b antikoerper, transcription factor 7 like 1a antikoerper, TCF7L1 antikoerper, Tcf7l1 antikoerper, tcf7l1.L antikoerper, tcf7l1.S antikoerper, tcf7l1b antikoerper, tcf7l1a antikoerper

Hintergrund: TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.
Alias Symbols: TCF-3, TCF3
Protein Interaction Partner: UBC, mdfic, Mdfi, DAZAP2, CTNNB1,
Protein Size: 588

Molekulargewicht: 63 kDa

Gen-ID: 83439

NCBI Accession: NM_031283, NP_112573

UniProt: Q9HCS4

Pathways: WNT Signalweg, Stem Cell Maintenance