DFFA Antikörper (N-Term)
-
- Target Alle DFFA Antikörper anzeigen
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
-
Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser DFFA Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL
- Homologie
- Cow: 92%, Dog: 83%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 83%, Rat: 92%
- Produktmerkmale
- This is a rabbit polyclonal antibody against DFFA. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human DFFA
- Top Product
- Discover our top product DFFA Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 331 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Andere Bezeichnung
- DFFA (DFFA Produkte)
- Synonyme
- DFF-45 antikoerper, DFF1 antikoerper, ICAD antikoerper, A330085O09Rik antikoerper, DFF35 antikoerper, Dff45 antikoerper, ICAD-L antikoerper, ICAD-S antikoerper, DFFA antikoerper, zgc:92229 antikoerper, DNA fragmentation factor subunit alpha antikoerper, DNA fragmentation factor, alpha subunit antikoerper, DNA fragmentation factor, 45kDa, alpha polypeptide antikoerper, DNA fragmentation factor, alpha polypeptide antikoerper, DFFA antikoerper, Dffa antikoerper, dffa antikoerper
- Hintergrund
-
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DFF-45, DFF1, Ion ChannelAD, ICAD
Protein Interaction Partner: DFFB, UBC, TUBB, ATG3, ISOC1, BZW2, MAT2B, FERMT2, TUBA1A, CNBP, RPS6KA3, PPP5C, PFAS, MAT2A, EIF6, GAPDH, EIF5, CTPS1, CKB, GZMB, CASP7, CASP3, GZMM, TOM1L2, SEPT5, YWHAZ, YWHAG, PRKAA2, STRN4, NECAB2, CIDEB, EWSR1, NAP1L5, TMBIM4, USP15, HERC1, MCC, BAK
Protein Size: 331 - Molekulargewicht
- 37 kDa
- Gen-ID
- 1676
- NCBI Accession
- NM_004401, NP_004392
- UniProt
- O00273
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose
-