DVL1 Antikörper (C-Term)
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- Target Alle DVL1 Antikörper anzeigen
- DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Meerschweinchen, Pferd, Saccharomyces cerevisiae
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DVL1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- AAGAGGSGSE SDHTAPSGVG SSWRERPAGQ LSRGSSPRSQ ASATAPGLPP
- Homologie
- Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%, Yeast: 85%
- Produktmerkmale
- This is a rabbit polyclonal antibody against DVL1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human DVL1
- Top Product
- Discover our top product DVL1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 670 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))
- Andere Bezeichnung
- DVL1 (DVL1 Produkte)
- Synonyme
- DVL antikoerper, DVL1L1 antikoerper, DVL1P1 antikoerper, Dvl antikoerper, mKIAA4029 antikoerper, dvl-1 antikoerper, DSH antikoerper, DVL-1 antikoerper, dvl1 antikoerper, dvl2l antikoerper, Xdsh antikoerper, dsh1 antikoerper, dishevelled segment polarity protein 1 antikoerper, dishevelled, dsh homolog 1 (Drosophila) antikoerper, microRNA 6808 antikoerper, dishevelled segment polarity protein 1b antikoerper, dishevelled segment polarity protein 1 L homeolog antikoerper, DVL1 antikoerper, Dvl1 antikoerper, MIR6808 antikoerper, dvl1b antikoerper, dvl1.L antikoerper
- Hintergrund
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DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: DVL, MGC54245, DVL1L1
Protein Interaction Partner: NCK2, TRIM69, NUMA1, HUWE1, UBC, DVL2, WWOX, SIPA1, PSMA3, LRRK2, ITCH, HECW1, NEDD4, ANXA7, SDC4, NKD2, CYLD, SIRT1, CCDC88C, VANGL1, CXXC4, PPM1A, DYNLT1, HDHD2, BRD7, DAAM1, AXIN1, USP13, SMAD3, SMAD7, FRAT1, RAC1, DVL3, SMAD2, DVL1, SMAD4, CSNK1D, CSN
Protein Size: 670 - Molekulargewicht
- 73 kDa
- Gen-ID
- 1855
- NCBI Accession
- NM_004421, NP_004412
- Pathways
- WNT Signalweg, Synaptic Membrane, Skeletal Muscle Fiber Development
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