EGR1 Antikörper (N-Term)

Produktnummer ABIN2779517

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EGR1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Pferd, Rind (Kuh), Kaninchen und Schwein und wurde in 7+ Publikationen erwähnt.

Kurzübersicht für EGR1 Antikörper (N-Term) (ABIN2779517)

Target: EGR1 (Early Growth Response 1 (EGR1))

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-EGR1 Antikörper

Bindungsspezifität: N-Term

Sequenz: DNYPKLEEMM LLSNGAPQFL GAAGAPEGSG SNSSSSSSGG GGGGGGGSNS

Homologie: Cow: 87%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against EGR1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EGR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 543 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-EGR1 Antikörper (ABIN2779517)

Balakrishnan, Stykel, Touahri, Stratton, Biernaskie, Schuurmans: "Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve." in: PLoS ONE, Vol. 11, Issue 4, pp. e0153256, (2016) (PubMed).

Ohata, Yamazaki, Kawai, Tsugawa, Tachikawa, Koinuma, Miyagawa, Kimoto, Nakayama, Namba, Yamamoto, Okano, Ozono, Michigami: "Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 29, Issue 7, pp. 1627-38, (2014) (PubMed).

Lane, Yu, Lackey, Chen, Marzluff, Cook: "Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins." in: PLoS ONE, Vol. 8, Issue 3, pp. e58456, (2013) (PubMed).

Revest, Kaouane, Mondin, Le Roux, Rougé-Pont, Vallée, Barik, Tronche, Desmedt, Piazza: "The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib." in: Molecular psychiatry, Vol. 15, Issue 12, pp. 1125, 1140-51, (2010) (PubMed).

Jaluria, Konstantopoulos, Betenbaugh, Shiloach: "Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates." in: Biotechnology and bioengineering, Vol. 99, Issue 6, pp. 1443-52, (2008) (PubMed).

Wenzel, Daskalow, Herse, Seitz, Zacharias, Schenk, Schulz, Hubner, Micheel, Schlag, Osterziel, Ozcelik, Scherneck, Jandrig: "Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway." in: Biological chemistry, Vol. 388, Issue 5, pp. 489-95, (2007) (PubMed).

Barbolina, Adley, Ariztia, Liu, Stack: "Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression." in: The Journal of biological chemistry, Vol. 282, Issue 7, pp. 4924-31, (2007) (PubMed).

Details zu EGR1

Target: EGR1 (Early Growth Response 1 (EGR1))

Andere Bezeichnung: EGR1

Hintergrund: Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225
Protein Interaction Partner: CEBPB, WT1, SUMO1, TP53, MDM2, EP300, CDKN2A, SRA1, IL1B, PTEN, SP1, SNAI1, TBX2, PFDN5, SREBF2, ERBB3, NAB2, PITX1, NAB1, NFATC2, CREBBP, PSMA3, JUN, RELA, CSNK2A1, NFATC1, GADD45B, GADD45A,
Protein Size: 543

Molekulargewicht: 57 kDa

Gen-ID: 1958

NCBI Accession: NM_001964, NP_001955

UniProt: P18146

Pathways: Regulation of Carbohydrate Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity