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ETV4 Antikörper (Middle Region)

ETV4 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Pferd, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2779533
  • Target Alle ETV4 Antikörper anzeigen
    ETV4 (Ets Variant 4 (ETV4))
    Bindungsspezifität
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Pferd, Kaninchen
    Wirt
    • 24
    • 2
    • 1
    Kaninchen
    Klonalität
    • 25
    • 2
    Polyklonal
    Konjugat
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ETV4 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 10
    • 9
    • 6
    • 5
    • 4
    • 1
    Western Blotting (WB)
    Sequenz
    HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH
    Homologie
    Cow: 100%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against ETV4. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human ETV4
    Top Product
    Discover our top product ETV4 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 484 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Kedage, Selvaraj, Nicholas, Budka, Plotnik, Jerde, Hollenhorst: "An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer." in: Cell reports, Vol. 17, Issue 5, pp. 1289-1301, (2016) (PubMed).

    Okimoto, Breitenbuecher, Olivas, Wu, Gini, Hofree, Asthana, Hrustanovic, Flanagan, Tulpule, Blakely, Haringsma, Simmons, Gowen, Suh, Miller, Ali, Schuler, Bivona: "Inactivation of Capicua drives cancer metastasis." in: Nature genetics, Vol. 49, Issue 1, pp. 87-96, (2016) (PubMed).

    Selvaraj, Budka, Ferris, Jerde, Hollenhorst: "Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation." in: Molecular cancer, Vol. 13, pp. 61, (2014) (PubMed).

    Hollenhorst, Paul, Ferris, Graves: "The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells." in: Genes & cancer, Vol. 1, Issue 10, pp. 1044-1052, (2011) (PubMed).

    Hollenhorst, Ferris, Hull, Chae, Kim, Graves: "Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells." in: Genes & development, Vol. 25, Issue 20, pp. 2147-57, (2011) (PubMed).

  • Target
    ETV4 (Ets Variant 4 (ETV4))
    Andere Bezeichnung
    ETV4 (ETV4 Produkte)
    Synonyme
    E1A-F antikoerper, E1AF antikoerper, PEA3 antikoerper, PEAS3 antikoerper, Pea3 antikoerper, AW414408 antikoerper, Pea-3 antikoerper, pea3 antikoerper, ETS variant 4 antikoerper, ets variant 4 antikoerper, ETV4 antikoerper, Etv4 antikoerper, etv4 antikoerper
    Hintergrund
    The protein encoded by the ETV4 gene is known to play a role in ovarian and breast malignancies as well as in the early stage of colorectal carcinogenesis.
    Alias Symbols: E1A-F, E1AF, PEA3, PEAS3
    Protein Interaction Partner: STK11, RFWD2, TP63, ATXN1, HTT, APP, UBC, SMAD2, SUMO2, SUMO1, SAE1, UBA2, HOXD4, EP300, SRF,
    Protein Size: 484
    Molekulargewicht
    54 kDa
    Gen-ID
    2118
    NCBI Accession
    NM_001986, NP_001977
    UniProt
    P43268
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