RUVBL1 Antikörper (N-Term)
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- Target Alle RUVBL1 Antikörper anzeigen
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Ziege
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RUVBL1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- KIEEVKSTTK TQRIASHSHV KGLGLDESGL AKQAASGLVG QENAREACGV
- Homologie
- Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against RUVBL1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human RUVBL1
- Top Product
- Discover our top product RUVBL1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 456 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
- Andere Bezeichnung
- RUVBL1 (RUVBL1 Produkte)
- Synonyme
- rvb1 antikoerper, ecp54 antikoerper, tip49 antikoerper, nmp238 antikoerper, pontin antikoerper, tip49a antikoerper, xpontin antikoerper, pontin52 antikoerper, TIP49 antikoerper, wu:fd18e04 antikoerper, zpontin antikoerper, ECP54 antikoerper, INO80H antikoerper, NMP238 antikoerper, PONTIN antikoerper, Pontin52 antikoerper, RVB1 antikoerper, TIH1 antikoerper, TIP49A antikoerper, Tip49a antikoerper, 2510009G06Rik antikoerper, RuvB like AAA ATPase 1 antikoerper, RuvB-like 1 (E. coli) antikoerper, RuvB-like 1 antikoerper, RuvB like AAA ATPase 1 S homeolog antikoerper, RuvB-like AAA ATPase 1 antikoerper, RuvB-like protein 1 antikoerper, RUVBL1 antikoerper, ruvbl1 antikoerper, PVX_123295 antikoerper, Bm1_15605 antikoerper, ruvb1 antikoerper, ruvbl1.S antikoerper, Ruvbl1 antikoerper
- Hintergrund
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RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Alias Symbols: ECP54, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49A, INO80H, PONTIN
Protein Interaction Partner: RUVBL2, HUWE1, CEP250, RPAP3, UBC, NEDD8, SUMO1, RNF2, EED, rev, NEDD4, CDC42, IQGAP1, PARK2, FBXO6, USP49, FBXO46, FBXW4, RBM8A, TELO2, TTI1, URI1, RUVBL1, TRRAP, TUBA1A, TUBB, SMG9, UPF1, PRKDC, POLR2E, NCBP1, LMNA, HSPA4, SMG8, PIH1D1, PABPC1, SMG1, PA
Protein Size: 456 - Molekulargewicht
- 50 kDa
- Gen-ID
- 8607
- NCBI Accession
- NM_003707, NP_003698
- UniProt
- Q9Y265
- Pathways
- Telomere Maintenance
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