NCOA3 Antikörper (Middle Region)

Produktnummer ABIN2779677

Produktdetails anti-NCOA3 Antikörper

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: DQNPVESSMC QSNSRDHLSD KESKESSVEG AENQRGPLES KGHKKLLQLL

Homologie: Cow: 77%, Dog: 90%, Horse: 92%, Human: 100%, Mouse: 83%, Pig: 92%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NCOA3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NCOA3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1420 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Andere Bezeichnung: NCOA3 (NCOA3 Produkte)

Synonyme: NCOA3 antikoerper, ACTR antikoerper, AIB-1 antikoerper, AIB1 antikoerper, CAGH16 antikoerper, CTG26 antikoerper, KAT13B antikoerper, RAC3 antikoerper, SRC-3 antikoerper, SRC3 antikoerper, TNRC14 antikoerper, TNRC16 antikoerper, TRAM-1 antikoerper, bHLHe42 antikoerper, pCIP antikoerper, 2010305B15Rik antikoerper, AW321064 antikoerper, Actr antikoerper, Aib1 antikoerper, Rac3 antikoerper, Src3 antikoerper, Tram-1 antikoerper, Tram1 antikoerper, p/Cip antikoerper, pCip antikoerper, actr antikoerper, aib-1 antikoerper, aib1 antikoerper, cagh16 antikoerper, ctg26 antikoerper, kat13b antikoerper, pcip antikoerper, rac3 antikoerper, src-3 antikoerper, src3 antikoerper, tnrc14 antikoerper, tnrc16 antikoerper, tram-1 antikoerper, xSRC-3 antikoerper, nuclear receptor coactivator 3 antikoerper, nuclear receptor coactivator 3 S homeolog antikoerper, NCOA3 antikoerper, Ncoa3 antikoerper, ncoa3.S antikoerper

Hintergrund: NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
Alias Symbols: ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, MGC141848, RAC3, SRC-1, SRC3, TNRC14, TNRC16, TRAM-1, pCIP, SRC-3, bHLHe42
Protein Interaction Partner: PSMB9, PPARG, CUL3, ARNT2, MMS19, FBXW7, SPOP, UBC, E2F1, PTEN, ESR2, ALB, NR1I2, THRB, CHUK, KANK2, ESR1, NR3C1, MYOCD, MKL1, MKL2, PSME3, UBE3A, TP53, RARA, MAPK1, PIN1, PGR, EP300, ELAVL1, MAPK14, CREBBP, CEBPD, CEBPA, TP53BP1, TFF1, PSMC5, PSMA3, PRKC
Protein Size: 1420

Molekulargewicht: 155 kDa

Gen-ID: 8202

NCBI Accession: NM_006534, NP_006525

UniProt: Q0VF45

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha