GFI1 Antikörper (N-Term)

Produktnummer ABIN2779720

Produktdetails anti-GFI1 Antikörper

Target: GFI1 (Growth Factor Independent 1 (GFI1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VPAPSRADST SNAGGAKAEP RDRLSPESQL TEAPDRASAS PDSCEGSVCE

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 79%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GFI1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GFI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 422 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GFI1

Target: GFI1 (Growth Factor Independent 1 (GFI1))

Andere Bezeichnung: GFI1 (GFI1 Produkte)

Synonyme: AW495828 antikoerper, Gfi-1 antikoerper, Pal-1 antikoerper, Pal1 antikoerper, GFI1 antikoerper, GFI-1 antikoerper, GFI1A antikoerper, SCN2 antikoerper, ZNF163 antikoerper, growth factor independent 1 antikoerper, growth factor independent 1 transcriptional repressor antikoerper, Gfi1 antikoerper, GFI1 antikoerper

Hintergrund: GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Alias Symbols: ZNF163, SCN2, GFI-1
Protein Interaction Partner: RELA, SPI1, CHAF1A, PICK1, PIAS2, RCOR1, KDM1A, HDAC2, PRDM5, HDAC1, EHMT2, PIAS3, RUNX1T1, ARIH2, UBC,
Protein Size: 422

Molekulargewicht: 45 kDa

Gen-ID: 2672

NCBI Accession: NM_005263, NP_005254

UniProt: Q99684