HIPK2 Antikörper (Middle Region)

Produktnummer ABIN2779735

Produktdetails anti-HIPK2 Antikörper

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIPK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MWSLGCVIAE LFLGWPLYPG ASEYDQIRYI SQTQGLPAEY LLSAGTKTTR

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 87%

Produktmerkmale: This is a rabbit polyclonal antibody against HIPK2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human HIPK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1198 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HIPK2 Antikörper (ABIN2779735)

Upadhyay, Bhadauriya, Ganesh: "Heat shock modulates the subcellular localization, stability, and activity of HIPK2." in: Biochemical and biophysical research communications, Vol. 472, Issue 4, pp. 580-4, (2016) (PubMed).

Steinmann, Schulte, Beck, Chachra, Bujnicki, Klempnauer: "v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300." in: Oncogene, Vol. 28, Issue 26, pp. 2446-55, (2009) (PubMed).

Choi, Seo, Kim, Sung, Ahn, Park, Lee, Choi: "Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1." in: The Journal of biological chemistry, Vol. 283, Issue 8, pp. 4682-9, (2008) (PubMed).

Details zu HIPK2

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Andere Bezeichnung: HIPK2 (HIPK2 Produkte)

Synonyme: HIPK2 antikoerper, cb1009 antikoerper, si:dkey-16j24.2 antikoerper, si:dkey-239k7.1 antikoerper, wu:fk56d12 antikoerper, pro0593 antikoerper, MGC146781 antikoerper, PRO0593 antikoerper, 1110014O20Rik antikoerper, B230339E18Rik antikoerper, Stank antikoerper, PKM antikoerper, homeodomain interacting protein kinase 2 antikoerper, serine/threonine kinase antikoerper, homeodomain interacting protein kinase 2 L homeolog antikoerper, HIPK2 antikoerper, Smp_000720 antikoerper, hipk2 antikoerper, hipk2.L antikoerper, Hipk2 antikoerper

Hintergrund: HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.
Alias Symbols: DKFZp686K02111, FLJ23711, PRO0593
Protein Interaction Partner: UBC, TP53, SIAH2, XAF1, AATF, SUMO1, MDM2, AXIN1, SIAH1, MBP, DAXX, MKNK1, MECP2, ZBTB4, HIPK2, DCAF7, DYRK1B, MAP3K1, DYRK1A, FBXO3, CBX4, SUMO2, SUMO3, PML, PAX6, CHMP4B, SENP2, SENP1, UBE2I, HIST2H2BE, CXCL1, SIAH1P1, WSB1, MYBL2, MYBL1, NLK, MAP3K7, M
Protein Size: 1198

Molekulargewicht: 120 kDa

Gen-ID: 28996

NCBI Accession: NM_022740, NP_073577

UniProt: Q9H2X6

Pathways: Zellzyklus