APEX1 Antikörper (N-Term)
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- Target Alle APEX1 Antikörper anzeigen
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen, Ziege
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser APEX1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- KGLDWVKEEA PDILCLQETK CSENKLPAEL QELPGLSHQY WSAPSDKEGY
- Homologie
- Cow: 92%, Dog: 92%, Goat: 83%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%
- Produktmerkmale
- This is a rabbit polyclonal antibody against APEX1. It was validated on Western Blot and immunohistochemistry.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human APEX1
- Top Product
- Discover our top product APEX1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 318 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
- Andere Bezeichnung
- APEX1 (APEX1 Produkte)
- Synonyme
- apex1 antikoerper, MGC76280 antikoerper, MGC79645 antikoerper, MGC78928 antikoerper, APE antikoerper, APE1 antikoerper, APEN antikoerper, APEX antikoerper, APX antikoerper, HAP1 antikoerper, REF1 antikoerper, Apex antikoerper, REF-1 antikoerper, BAP1 antikoerper, apex1a antikoerper, hm:zehn1532 antikoerper, wu:fc13d11 antikoerper, zgc:66204 antikoerper, Ref-1 antikoerper, apurinic/apyrimidinic endodeoxyribonuclease 1 antikoerper, APEX nuclease (multifunctional DNA repair enzyme) 1 antikoerper, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog antikoerper, DNA-(apurinic or apyrimidinic site) lyase antikoerper, apurinic/apyrimidinic endonuclease 1 antikoerper, APEX1 antikoerper, apex1 antikoerper, apex1.L antikoerper, CNG03640 antikoerper, CNH01280 antikoerper, nth antikoerper, Spirs_4119 antikoerper, Palpr_0103 antikoerper, Apex1 antikoerper
- Hintergrund
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.
Alias Symbols: APE, APX, APE1, APEN, APEX, HAP1, REF1
Protein Interaction Partner: GADD45A, UBC, RPA3, RPA2, RPA1, rev, CCDC124, RIC8A, PABPC1, TWF2, XPOT, HNRNPUL1, ARIH2, PAPSS2, NAE1, PSMG1, TXNRD1, TXN, TCEB1, LGALS1, HNRNPK, CAPNS1, SRPK2, SRPK1, MUTYH, HMGA1, HMGA2, GZMK, GZMA, YBX1, EP300, ASCL2, STAT3, SNRPD1, SFPQ, APP, UBE2I,
Protein Size: 318 - Molekulargewicht
- 35 kDa
- Gen-ID
- 328
- NCBI Accession
- NM_080648, NP_542379
- UniProt
- P27695
- Pathways
- DNA Reparatur, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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