ACD Antikörper (C-Term)
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- Target Alle ACD Antikörper anzeigen
- ACD (Adrenocortical Dysplasia Homolog (ACD))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ACD Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA
- Homologie
- Cow: 83%, Dog: 85%, Guinea Pig: 85%, Horse: 85%, Human: 85%, Mouse: 100%, Rat: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Acd. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the c terminal region of mouse Acd
- Top Product
- Discover our top product ACD Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 416 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ACD (Adrenocortical Dysplasia Homolog (ACD))
- Andere Bezeichnung
- Acd (ACD Produkte)
- Synonyme
- PIP1 antikoerper, PTOP antikoerper, TINT1 antikoerper, TPP1 antikoerper, ACD antikoerper, ACD, shelterin complex subunit and telomerase recruitment factor antikoerper, adrenocortical dysplasia antikoerper, ACD antikoerper, Acd antikoerper
- Hintergrund
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Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.
Alias Symbols: -
Protein Size: 416 - Molekulargewicht
- 45 kDa
- Gen-ID
- 497652
- NCBI Accession
- NM_001012638, NP_001012656
- UniProt
- Q5EE38
- Pathways
- Telomere Maintenance
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