MCAF1 Antikörper (Middle Region)

Produktnummer ABIN2780013

Produktdetails anti-MCAF1 Antikörper

Target: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Bindungsspezifität: Middle Region

Reaktivität: Schwein, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MSTPEGEKSE KDGKAEEEER VPAEEQPPVR NEFSRRKRSK SEDMDSVESK

Homologie: Mouse: 100%, Pig: 92%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against Atf7ip. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Atf7ip

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1306 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MCAF1

Target: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Andere Bezeichnung: Atf7ip (ATF7IP Produkte)

Synonyme: ATF7IP antikoerper, AM antikoerper, MCAF antikoerper, MCAF1 antikoerper, p621 antikoerper, 2610204M12Rik antikoerper, Mcaf1 antikoerper, fa12g02 antikoerper, wu:fa12g02 antikoerper, zgc:152981 antikoerper, activating transcription factor 7 interacting protein antikoerper, Atf7ip antikoerper, ATF7IP antikoerper, atf7ip antikoerper

Hintergrund: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.
Alias Symbols: 2610204M12Rik, AM, Mcaf1
Protein Interaction Partner: Atf7, Gtf2f1, Gtf2e2, Aagab, Ccnh, Gtf2h1, Ercc3, Cdk7, C1qbp, POLR2H, POLR2G, POLR2D, POLR2C,
Protein Size: 1306

Molekulargewicht: 138 kDa

Gen-ID: 54343

NCBI Accession: NM_019426, NP_062299

UniProt: Q7TT18