NMRAL1 Antikörper (N-Term)

Produktnummer ABIN2780056

Produktdetails anti-NMRAL1 Antikörper

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Bindungsspezifität: N-Term

Reaktivität: Ratte, Maus, Rind (Kuh), Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMRAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD

Homologie: Cow: 79%, Dog: 79%, Mouse: 100%, Pig: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against Nmral1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of mouse Nmral1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 309 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NMRAL1

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Andere Bezeichnung: Nmral1 (NMRAL1 Produkte)

Synonyme: HSCARG antikoerper, SDR48A1 antikoerper, 1110025F24Rik antikoerper, AI256624 antikoerper, RGD1311451 antikoerper, NmrA like redox sensor 1 antikoerper, NmrA-like family domain containing 1 antikoerper, NMRAL1 antikoerper, Nmral1 antikoerper

Hintergrund: Nmral1 is a redox sensor protein. Nmral1 undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH.Nmral1 has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.
Alias Symbols: 1110025F24Rik, AI256624
Protein Size: 309

Molekulargewicht: 34 kDa

Gen-ID: 67824

NCBI Accession: NM_026393, NP_080669

UniProt: Q8K2T1