FBXW7 Antikörper (Middle Region)
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- Target Alle FBXW7 Antikörper anzeigen
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FBXW7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Fbxw7. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of mouse Fbxw7
- Top Product
- Discover our top product FBXW7 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 629 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression." in: Oncotarget, Vol. 5, Issue 2, pp. 493-505, (2014) (PubMed).
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NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression." in: Oncotarget, Vol. 5, Issue 2, pp. 493-505, (2014) (PubMed).
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- Target
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Andere Bezeichnung
- Fbxw7 (FBXW7 Produkte)
- Synonyme
- cdc4 antikoerper, AGO antikoerper, CDC4 antikoerper, FBW6 antikoerper, FBW7 antikoerper, FBX30 antikoerper, FBXO30 antikoerper, FBXW6 antikoerper, SEL-10 antikoerper, SEL10 antikoerper, hAgo antikoerper, hCdc4 antikoerper, 1110001A17Rik antikoerper, Cdc4 antikoerper, Fbw7 antikoerper, Fbwd6 antikoerper, Fbx30 antikoerper, Fbxo30 antikoerper, Fbxw6 antikoerper, F-box and WD repeat domain containing 7 antikoerper, F-box and WD-40 domain protein 7 antikoerper, Fbxw7 antikoerper, FBXW7 antikoerper, fbxw7 antikoerper
- Hintergrund
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Alias Symbols: 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Protein Interaction Partner: Skp1a, CREB3L1, CREB3L2, Cul1, Prkcz, Prkce, Prkcd, Prkcb, Prkca, Pten, Mcl1, CEBPA, Pin1, MYB, Npm1, Jun,
Protein Size: 629 - Molekulargewicht
- 70 kDa
- Gen-ID
- 50754
- NCBI Accession
- NM_080428, NP_536353
- UniProt
- Q8VBV4
- Pathways
- Notch Signalweg, EGFR Signaling Pathway
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