Nkx2-2 Antikörper (N-Term)

Produktnummer ABIN2780436

Produktdetails anti-Nkx2-2 Antikörper

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Schaf, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nkx2-2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NKX2-2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NKX2-2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 273 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Nkx2-2 Antikörper (ABIN2780436)

Owen, Kowalewski, Lessnick: "EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma." in: PLoS ONE, Vol. 3, Issue 4, pp. e1965, (2008) (PubMed).

Details zu Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Andere Bezeichnung: NKX2-2 (Nkx2-2 Produkte)

Synonyme: XeNK-2 antikoerper, Xnkx2.2 antikoerper, nkx2-2-A antikoerper, nkx2.2 antikoerper, NKX-2.2 antikoerper, NKX2.2 antikoerper, NKX2B antikoerper, Nkx-2.2 antikoerper, Nkx2.2 antikoerper, tinman antikoerper, id:ibd5090 antikoerper, nk2.2 antikoerper, nkx2-2 antikoerper, wu:fc83b01 antikoerper, zgc:136536 antikoerper, NK2 homeobox 2 S homeolog antikoerper, NK2 homeobox 2 antikoerper, NK2 homeobox 2a antikoerper, nkx2-2.S antikoerper, NKX2-2 antikoerper, Nkx2-2 antikoerper, nkx2.2a antikoerper

Hintergrund: Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
Alias Symbols: NKX2.2, NKX2B
Protein Interaction Partner: Dlg4, SIN3A, HDAC1, OLIG2,
Protein Size: 273

Molekulargewicht: 30 kDa

Gen-ID: 4821

NCBI Accession: NM_002509, NP_002500

UniProt: O95096

Pathways: Dopaminergic Neurogenesis