SIAH1 Antikörper (C-Term)

Produktnummer ABIN2780459

Produktdetails anti-SIAH1 Antikörper

Target: SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIAH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LVLEKQEKYD GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SIAH1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIAH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 282 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SIAH1

Target: SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))

Andere Bezeichnung: SIAH1 (SIAH1 Produkte)

Synonyme: SIAH antikoerper, Siah1 antikoerper, Siah1a antikoerper, id:ibd2635 antikoerper, zgc:56026 antikoerper, SIAH1A antikoerper, siah antikoerper, E3 ubiquitin-protein ligase Siah1 antikoerper, E3 ubiquitin-protein ligase siah-1 antikoerper, siah E3 ubiquitin protein ligase 1 antikoerper, siah E3 ubiquitin protein ligase 1 L homeolog antikoerper, Tsp_03055 antikoerper, siah-1 antikoerper, Siah1 antikoerper, siah1 antikoerper, SIAH1 antikoerper, siah1.L antikoerper

Hintergrund: SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterizedThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alias Symbols: SIAH1A
Protein Interaction Partner: MX1, MAB21L1, KIFC3, KCNJ10, INHA, UBE2K, FLI1, EEF1D, PHC2, PHC1, CDC34, CAPG, BCL6, TRIM23, AQP1, PFKM, ZCCHC13, MTIF3, UPP2, MOB3C, SPATA4, PRR20A, HIST4H4, EXOC3-AS1, PTPMT1, RPS19BP1, SPATC1L, KATNAL1, TRIM7, GDPD5, ZBP1, KIAA1683, ARMC9, KIAA0319L,
Protein Size: 282

Molekulargewicht: 31 kDa

Gen-ID: 6477

NCBI Accession: NM_003031, NP_003022

UniProt: Q8IUQ4