SAP30 Antikörper (N-Term)

Produktnummer ABIN183646

Produktdetails anti-SAP30 Antikörper

Target: SAP30 (Sin3A-Associated Protein, 30kDa (SAP30))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Kaninchen, Ratte, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SAP30 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MNGFTPDEMS RGGDAAAAVA AVVAAAAAAA SAGNGTGAGT GAEVPGAGAV

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SAP30. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SAP30

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 220 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SAP30

Target: SAP30 (Sin3A-Associated Protein, 30kDa (SAP30))

Andere Bezeichnung: SAP30 (SAP30 Produkte)

Synonyme: 30kDa antikoerper, Sin3A associated protein 30 antikoerper, sin3 associated polypeptide antikoerper, Sin3A associated protein 30kDa S homeolog antikoerper, SAP30 antikoerper, Sap30 antikoerper, sap30.S antikoerper

Hintergrund: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. SAP30 is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.
Protein Interaction Partner: HDAC3, CUL4B, DDB1, HDAC1, SIN3A, UBC, HDAC2, BRMS1L, ING1, ARID4A, SAMSN1, ZNF395, UBASH3B, RBBP7, RBBP4, CHD4, ALL1, TAF6, SMARCA2, SAP25, RBP1, HIST2H2BE, PCBD1, ID3, SAP30BP, HIST2H4A, HBP1, HIST1H2AL, BRMS1, CIR1, HIST3H3, NCOR1, NCOR2, MXD1, YY1, HT
Protein Size: 220

Molekulargewicht: 23 kDa

Gen-ID: 8819

NCBI Accession: NM_003864, NP_003855

UniProt: O75446